The world-class Bulyanhulu gold deposit (375 t Au) is in the Sukumaland greenstone belt, Northwestern Tanzania. The main mineralised quartz vein structure, termed Reef one, occurs at the contact of felsic metavolcanic rocks on the hanging wall and mafic metavolcanic rocks on the footwall. Reef one is dominated by massive quartz together with pyrite, pyrrhotite and minor chalcopyrite. Alteration in the footwall basalt is characterised by extensive chloritisation, calcification and silicification, which is strongest near the vein. Sericitisation also locally occurs adjacent to the vein. Metamorphic hornblende and plagioclase (albite) increase in abundance at a distance of 120 m from the vein and reflect the gradation into less altered rocks. The increasing abundance of chlorite, calcite, quartz and local sericite near Reef one, coupled by replacement textures suggests that most of these footwall minerals are the product of hydrothermal alteration, rather than regional metamorphism. Geochemical data shows slight enrichment in Ca, Fe and As towards the vein, whereas Zn in several drill holes becomes enriched away from Reef one. The Bulyanhulu gold deposit is a quartz-pyrite-chalcopyrite shear controlled vein with an adjacent extensive chlorite-quartz-calcite hydrothermal alteration zone (and a limited local sericite alteration zone) that passes to a hornblende-albite metamorphic assemblage further into the footwall.