Assessing the uncertainty and risk in mineral resource estimation is required for best practice and is implied by the public reporting codes in the categorisation of mineral resources and reserves. One industry best practice is quantifying the risk on future production for a given period, which can be done using two geostatistical approaches: conditional simulation and drill hole spacing studies based on estimation variances. Conditional simulation can provide a more complete and flexible answer to the problem, but it takes a fair amount of time to complete. Drill hole spacing studies are simpler, faster and can provide reasonable assessments of mineral resource uncertainty.This paper is a presentation of the principles, theory and practice of drill hole spacing studies. Various types of risk assessment are considered. Difficulties encountered in practice are discussed, and solutions are proposed. The important parameters impacting the results are reviewed. Examples of results and sensitivities are shown.CITATION:Verly, G, Postolski, T and Parker, H M, 2014. Assessing uncertainty with drill hole spacing studies - applications to mineral resources, in Proceedings Orebody Modelling and Strategic Mine Planning Symposium 2014, pp 109-118 (The Australasian Institute of Mining and Metallurgy: Melbourne).