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The Hellyer, Fossey, Que River and Mount Charter volcanic-hosted massive sulfide (VHMS) deposits occur within the Que-Hellyer volcanics of the Mount Read volcanics, Tasmania. These deposits occur along a 6 km strike length and are hosted by the same stratigraphic unit. We use a combination of whole-rock geochemistry, short wavelength infrared (SWIR) spectrometry, laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) analyses and compiled historic whole-rock geochemical data to develop district-scale vectors towards VHMS mineralisation.Strongly sericite and K-feldspar altered rocks concentrate along a linear trend from Hellyer, through Que River, to Mount Charter. Ishikawa alteration index values and whole-rock major and trace element concentrations provide exploration vectors towards mineralisation on a regional scale as significant enrichment and depletion trends. On a deposit scale, composition variations in white mica (sericite alteration), chlorite and K-feldspar are observed and reflected in whole-rock geochemical variations. Regional SWIR data from drill core support the prevalence of phengitic mica and high-Mg chlorite within footwall alteration halos and highlight the main upflow zones of hydrothermal fluids in the VHMS district. The combined use of regional whole-rock geochemistry, SWIR and mineral chemistry is an effective way to highlight prospective areas for VHMS mineralisation in a mature exploration province.CITATION:Wu, S, Gemmell, J B, McNeill, A W and Richardson, S M, 2015. Exploration implications from variations in whole-rock and mineral chemistry around the volcanic-hosted massive sulfide deposits of the Que-Hellyer volcanics, Tasmania, Australia , in Proceedings PACRIM 2015 Congress, pp 85-90 (The Australasian Institute of Mining and Metallurgy: Melbourne).