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The Yaojialing zinc-gold polymetallic deposit is a newly discovered, large skarn deposit in the Middle-Lower Yangtze metallogenic belt, East China. It is located in the transitional zone between the Tongling uplift block and the Fanchang faulted basin. It is mainly hosted in the contact zone between early Cretaceous granodiorite porphyry and Carboniferous-Triassic limestone, or occurs in limestone xenoliths within the intrusion. Skarn and stratabound massive sulfide orebodies are the primary ore styles. Sulfide d34SV-CDT values indicate a magmatic sulfur source, in common with most deposits in the Tongling block. Calcite 13CV-PDB and 18OV-SMOW ratios reveal that marine carbonates were the major source of carbon in late-stage hydrothermal fluids. The calcite probably formed during interaction between magmatic fluids and carbonate wall rock.CITATION:Zhong, G X, Zhou, T F and Chang, Z S, 2015. Geology, chronology and isotope geochemistry of the Yaojialing zinc-gold deposit, Tongling ore district, Anhui Province, China, in Proceedings PACRIM 2015 Congress, pp 457-462 (The Australasian Institute of Mining and Metallurgy: Melbourne).