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Iron oxide-copper-gold (IOCG) systems of the Carajs mineral province (Amazon craton, Brazil) are structurally controlled by regional-scale shear zones and have formed by multiple episodes of fluid circulation and hydrothermal alteration in the Neoarchean (2.71-2.68 Ga and 2.56 Ga) and Palaeoproterozoic (1.90-1.87 Ga).Collectively, fluid inclusion, boron, oxygen and hydrogen isotope data and Cl/Br-Na/Cl ratios in fluid inclusions reveal that regional circulation of non-magmatic brines (eg evaporative fluids/evolved sea water) and mixing with other fluid sources (eg meteoric or magmatic) is an important attribute in the genesis of the Carajs IOCG systems. The 33S and 34S compositions of sulfides from the Neoarchean and Palaeoproterozoic IOCG systems suggest that the ore-bearing fluids have assimilated sulfur from crustal reservoirs. Nevertheless, most 33S measurements have indicated mass independent fractionation (MIF) effect for both systems which points to the possible involvement of surface sulfur sources.CITATION:Xavier, R P, Monteiro, L V S, Moreto, C P N, Melo, G H C and Santiago, E S B, 2015. Non-magmatic versus magmatic fluids in the genesis of Archean and Palaeoproterozoic iron oxide-copper-gold systems of the Carajs Mineral Province (Brazil), in Proceedings PACRIM 2015 Congress, pp 281-288 (The Australasian Institute of Mining and Metallurgy: Melbourne).