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The Mesozoic iron oxide-copper-gold (IOCG) mineralisation in southern Per and the northern Chile coastal IOCG belt have emerged as two of the major exploration targets in the Central Andes in the last two decades. These Mesozoic Andean IOCG deposits formed in two mineralisation epochs, the Middle-Late Jurassic (170-150 Ma) and Early Cretaceous (130-110 Ma), with the major Cu-rich IOCG deposits located in the Early Cretaceous mineralisation belt. The early studies in some IOCG centres support a magmtic-hydrothermal model for both Cu-rich IOCG deposits and broadly contemporaneous Cu-poor Kiruna-type' magnetite deposits. However, recent evidence from field, geochronology, fluid inclusions and stable isotopes show that in the major Central Andean deposits (eg Ral-Condestable, Mina Justa in southern Per, La Candelaria-Punta del Cobre and Mantoverde in northern Chile), the incursion of evaporite-sourced basinal brines or sea water may be a prerequisite for economic Cu mineralisation. Moreover, the Cu-poor massive magnetite deposits could be interpreted as a product from iron oxide melt, with minimal intervention by non-magmatic fluids. Therefore, they could represent two contrasted deposit types and contain little genetic relationships. The different roles of magmatism during the Mesozoic are responsible for the variable mineralisation in the Central Andes, including IOCG, magnetite and manto-type' deposits. The ore modelling for both the Middle-Late Jurassic and Early Cretaceous metallogenic epochs in the Central Andes are reconstructed.CITATION:Chen, H, 2015. The Mesozoic iron oxide-copper-gold (IOCG) mineralisation in the Central Andes - a refined IOCG ore-forming model in the Palaeozoic Continental Margin, in Proceedings PACRIM 2015 Congress, pp 251-254 (The Australasian Institute of Mining and Metallurgy: Melbourne).