Widely diverse mechanisms exist for the action of a range of selective sulphide flotation depressants. Collector desorp- tion, leaching, competitive adsorption, formation of hydrophilic reaction-product coatings, action as reducing agents, and action as lattice-oxidizing agents are discussed. Detailed attention is focused on the latter two mechanisms. Recent works on copper depressants particularly for copper-molybdenum separations, and oxidizing agents enabling arsenopyrite- pyrite separations, are presented and discussed.