Dissolution of S02 into water-acetone mixtures results in the formation of 2-hydroxy-2-propane sulphonic acid. The pH, or acid strength, of water-carbonyl-S02 mix- tures can be controlled by varying the concen- tration of the carbonyl compound or the rate at which S02 is added to the water-carbonyl mixture during a reaction. The ease with which the acid strength of these mixtures can be controlled means that they have significant potential for use as a selective lixiviant. We have used water-acetone-S02 mixtures to selectively dissolve phosphate minerals in Christmas Island and Duchess phosphate ores and also uranium minerals in Yeelirrie uranium ore and Olympic Dam copper concentrate.