Refractory ores need to be pretreated prior to cyanide leaching for acceptable gold recovery. Pressure oxidation is one method of rendering the ores more suitable for cyanidation. The focus of this work is optimisation of autoclave configuration for pressure oxidation. An autoclave for the pressure oxidation of a feed containing pyrite and arsenopyrite was modelled, using the population balance framework. The autoclave model takes into account feed particle size, reaction kinetics and retention time. Mass balance calculations were incorporated into Cycad Process software. This allowed for the investigation of different circuit configurations. The base case model consists of a single autoclave. The feed was then doubled and additional autoclaves were added to provide the same residence time as the base case. Four different configurations for the additional equipment were simulated. These were parallel, series, series with inter-stage thickening and parallel-series circuits. The options are compared in terms of extraction and productivity. The parallel circuit behaves similarly to the base case. The series and series-parallel circuits have higher recoveries and productivities than the base case. The series circuit with inter-stage thickening provides the highest extraction and productivity. This is because the thickening reduces the slurry volume and increases the residence time of the solids in the downstream autoclave.CITATION:Saloojee, F and Crundwell, F K, 2013. Optimisation of circuits for gold pressure oxidation, in Proceedings World Gold 2013 , pp 181-188 (The Australasian Institute of Mining and Metallurgy: Melbourne).