Optimisation of mining projects is directly related to effective and efficient management of risks through the life cycle of mining projects. Effective and efficient management of risks must include explicitly all aspects of Occupational Health and Safety (OHS) through the life cycle of mining projects. This paper presents a different scale of OHS in the context of the optimisation of mining projects. Meaning of risk through the project life cycle is explained. Complex relationships between numerous risk, safety, knowledge, culture and change variables, and project life cycles are shown. The key element developed in this paper is a multi-disciplinary knowledge base that is necessary for constructive development of risk management and OHS models through the life cycle of mining projects.