The Mesozoic intrusive rocks in southeastern coastal China can be divided into three intrusive suites, and they can be brought into corresponding with four cycles of volcanic activity. This paper describes their time-space relation with volcanic rocks, and their geochemical characteristics. Data from the Mesozoic volcanic-intrusive. complex rocks in Eastern Zheijiang, Eastern Fujiang and Eastern Guangdong show distinct regional differences, both within and tectonomagmatic activity regions. The southeastern coast of China involves four tectonomagmatic activity regions. They have many differences on the nature of magma source regions, activity patterns of magma, time-space distribution, petrography and petrographic facies association of volcanic and intrusive rock and mineralization.