Polymetallic hydrothermal veins of the Western Cascades are hosted in propylitically altered Tertiary volcanics of calc-alkaline affinity and (or) in nearby, altered, and compositionally similar plutons. Ores from shallow and now abandoned mines produced mostly gold and were considered to be of epithermal origin. However, recent discovery of breccia and porphyry types of Cu-Mo mineralisation and other data suggest that the deposits of this terrane vary systematically both regionally, south to north, and locally, high to low altitudes. The evidence includes changes in (1) size, composition, and complexity of plutons, (2) types of mineral deposits; (3) assemblages of alteration and ore minerals; (4) trace metal geochemistry of host rocks; and (5) fluid inclusion and sulphur isotope data. They collectively imply a consanguineous origin of vein, breccia, and disseminated-veinlet types of mineralisation by magmatic hydrothermal processes.